Medical
Oral vs Injectable Wegovy

What We'll Cover:

  • What oral and injectable weight loss medications are
  • Similarities between oral and injectable Wegovy
  • Key differences and choosing the option that is right for you

What are oral and injectable weight loss medications?

Weight loss medications can help people lose weight when used alongside healthy eating, regular movement and other healthy lifestyle habits. 

There are now different forms of Wegovy (Semaglutide) available. Tablets that are taken by mouth and medications that are given as an injection. Weight loss outcomes with oral semaglutide are broadly comparable to the wegovy injection. 

If you are thinking about using weight loss medication or already use it, knowing the differences can help you to understand your options.

Similarities between oral and injectable Wegovy

There are two ways to take Wegovy:

Oral Wegovy medication: A tablet taken by mouth each day, following specific rules outlined in our article ‘A Guide to Taking Wegovy Tablets: The Four Rules’.

Injectable Wegovy medication: A weekly injection under the skin, following guidance provided in materials from your clinicians or primary prescriber.

Both are prescription medications which should not be taken without consulting a healthcare professional.

Although they are taken differently, oral and injectable Wegovy have many things in common:

  • Help support weight loss alongside healthy lifestyle changes
  • Require regular use to achieve the best results
  • Contain the active ingredient Semaglutide
  • Help reduce appetite and food cravings.
  • Can cause side effects, but these are different for everyone

It is important to remember that medication is only one part of a weight management plan. It works best when combined with healthy eating, physical activity and other healthy habits.

Key differences and choosing the option that is right for you

Oral Wegovy Injectable Wegovy
Taken as a tablet by mouth Injection under the skin
Taken daily Taken weekly
No injections needed Self-injection using a pen device
Easier for people who dislike needles Some people may find less frequent dosing more convenient
Clinical trial results showed up to 16.6% weight loss after 64 weeks2 Clinical trial results showed up to a 16.9% weight loss after 68 weeks3

There is no single best option. The right medication for you may depend on:

  • Your medical history and other medications you take
  • Your weight management goals
  • Potential side effects
  • Personal preference

Your primary prescriber can help you choose the option that is right for you and answer any questions. Our clinicians are also available if you would like more information.

Summary

Oral or injectable Wegovy can support weight loss when used alongside healthy lifestyle changes. They share many similarities, but differ in how they are taken. Speaking with your primary prescriber or clinician can help you make an informed decision about the approach that best suits you.

July 16, 2026
Page last reviewed:
July 16, 2026
Next review due:
Written by
Eugene Holmes
Reviewed by
Catherine Hyatt
adattamento a cura del

The information on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional for personalised medical guidance.

References

  1. UK Government. First GLP 1 tablet for weight loss approved in the UK [Internet]. GOV.UK. 2025 [cited 2026 June 25]. Available from: https://www.gov.uk/government/news/first-glp-1-tablet-for-weight-loss-approved-in-the-uk
  2. Wharton S, et al. Oral semaglutide for obesity: a phase 3 randomised controlled trial [Internet]. New England Journal of Medicine. 2025 [cited 2025 June 26]. Available from: https://pubmed.ncbi.nlm.nih.gov/40934115/
  3. O'Neil PM, et al. Oral semaglutide in adults with overweight or obesity: additional phase 3 clinical trial findings [Internet]. New England Journal of Medicine. 2025 [cited 2026 June 26]. Available from: https://pubmed.ncbi.nlm.nih.gov/40961952/ 

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