What we’ll cover:

• The connection between PMOS and obesity
• Effective treatments and support options for women with PMOS
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Polyendocrine metabolic ovarian syndrome (PMOS) is a condition that affects around 1 in 8 women worldwide. Until recently, the condition was known as Polycystic ovarian syndrome (PCOS). While PCOS was once treated as a gynecological problem, new research shows it is typically caused by hormonal imbalances within the body.

These imbalances can affect hair growth, periods, fertility and mood. Women with PMOS are also more likely to develop other health problems. This includes:

• Type 2 diabetes
• High blood pressure and cardiovascular disease
• Non-alcoholic fatty liver disease
• Womb (uterus) cancer
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How are PMOS and body weight related?

Weight management with PMOS can be challenging for a number of reasons: 

• Insulin resistance
  It is common for women living with PMOS to also have insulin resistance. This can make weight management more challenging, and increase the risk of type 2 diabetes.
  
  
• Hormonal changes
  Women with PMOS often have higher levels of hormones called androgens. This may contribute to symptoms such as acne, excess hair growth and irregular menstrual cycles. Along with other hormonal changes (such as insulin and testosterone not working as expected), these can cause the body to store excess fat - especially around the abdomen.
  
  
• Inflammation
  PMOS is associated with low-grade inflammation, which may contribute to insulin resistance and metabolic health. 
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How is PMOS treated?

PMOS is managed with a range of treatments to help control symptoms, though there isn’t a cure for the condition.

• Oral contraceptives
  Hormonal contraception may help regulate menstrual cycles and improve acne and excess hair growth.
  
  
• Anti-androgen medications
  May help reduce symptoms such as acne and unwanted hair growth.
  
  
• Metformin
  This medication may help regulate menstrual cycles for some women. It can also help to manage blood sugar levels.
  
  
• GLP-1 receptor agonists
  GLP-1 receptor agonists such as semaglutide (Wegovy) and tirzepatide (Mounjaro) can support weight management and improve metabolic health.
  
  
• Topical acne treatments
  Topical treatments and (where appropriate), oral medications can help manage acne.
  
  
• Hair removal treatments
  Laser therapy or other methods can address unwanted hair growth.

It is also possible to manage symptoms through diet and lifestyle changes. For more information, you can read our article on ‘Eating and living well with PMOS’.
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Seeking support

Managing PMOS and its challenges can feel overwhelming, but you don’t have to face it alone:

• Speak to your GP. They may be able to refer you to other healthcare professionals such as endocrinologists, gynaecologists, and nutritionists for tailored advice.
• Join support groups to connect with others who share similar experiences and strategies for coping.
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Summary

PMOS and obesity are closely linked. With the right strategies and support, women with PMOS can manage symptoms and improve health. Roczen is here to support you every step of the way on your journey to well-being.