What we’ll cover:

• What micro-dosing and the “fifth dose” mean in practice
• Why some people consider changing their dosing approach
• The potential risks of self-directed dose changes
• Safe ways to manage treatment concerns

What is micro-dosing?

When taking a GLP-1 medication, it is normal to seek support from others going through the same journey. Some people find it hard to talk to friends or family if they do not share the experience. Because of this, it is becoming more common to go on social media or online forums, to read or join discussions on GLP-1 medications.

If this sounds familiar, you may have come across terms like “micro-dosing” and “the fifth dose”. But what do they mean in practice?

Micro-dosing This means injecting smaller doses than prescribed in an attempt to make the pen last longer.

The “fifth dose”‍

The “fifth dose”, also known online as the “golden dose”, refers to the small amount of liquid left in the pen after the prescribed four injections. As stated in the manufacturer’s user manual, this extra liquid should not be used as an additional dose. Instead, it is there to help prime the pen, release a small amount, remove air from the cartridge, and ensure the pen is working.

Why some people consider changing their dose‍

Some people may think about changing how they take their medication for a range of personal reasons. These may include:

• Financial pressures when self-funding treatment
• Hoping that a smaller dose may help reduce side effects
• Influence from others online, on social media, or people close to them
• Difficulty accessing ongoing prescriptions or clinical support.

The potential risks of self-directed dose changes‍

Like any prescription medication, it is important to take GLP-1 treatment exactly as your doctor has prescribed. At Roczen, we do not promote micro-dosing or using the “fifth dose”.

This is for two main reasons. Firstly, there is currently no clinical evidence showing benefits from these methods. Most importantly, both micro-dosing and using the “fifth dose” could potentially be unsafe.

Potential risks include:

• A higher risk of side effects due to taking an unknown or inconsistent dose
• Reduced effectiveness if the dose is lower than intended
• Increased risk of contamination or infection when handling the pen differently
• The pen may not work properly (for example, it may jam or break) if used outside instructions
• The medication may be used outside its intended expiry date guidance.

Clinically supported ways to manage treatment concerns‍

Your prescribed dose has been chosen for you as an individual. It is tailored to your needs and treatment plan. We understand there may be concerns around dosage, side effects, or how well the medication is working. These worries are valid, and you are not alone in having them.

At Roczen, our clinical team is always here to help answer questions and talk through any concerns. If you are unsure about anything, it is best to speak with a healthcare professional before making any changes.

Summary‍

Micro-dosing GLP-1 medication and using the so-called “fifth dose” is not recommended. These approaches may carry safety risks and can affect how well treatment works. If you have any questions or concerns about your dose, your Roczen clinician is on hand to help.

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