What We’ll Cover:
HRT (hormone replacement therapy) can help manage symptoms of the menopause. It comes in different forms including tablets, patches, gels and sprays.
If you are taking a weight-management medicine, you may have questions about starting HRT or changing your HRT. This article explains some things to consider and when to speak with a healthcare professional.
Your healthcare professional can help you choose the right treatment for you. Do not stop or change your medicines without speaking to them first.
HRT replaces hormones that your body produces less of during menopause. It can help manage symptoms such as hot flushes, night sweats and vaginal symptoms.
There are different types of HRT. The right option depends on things such as your symptoms, whether you still have your womb and your personal preferences. Your healthcare professional can talk you through the options.
"If you are taking an oral HRT tablet alongside an incretin weight-management medicine, it is worth discussing this with your clinician. Weight-management treatments slow down how quickly your stomach empties, which can change how your body absorbs oral medications. If you notice your menopause symptoms returning or changing, your doctor can advise on whether adjusting your dose or switching to a non-oral option (like a patch or gel) might work better for you." Dr Raquel Sanchez Windt
HRT can help manage symptoms of the menopause, and there are different types and ways to use it.
If you take a weight-management medicine, speak with your healthcare professional before starting or changing HRT. Tell them about all the medicines and supplements you take.
Your healthcare professional can help you understand your options and decide what is right for you.
The information on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional for personalised medical guidance.
References
1. NHS. Treatment for menopause and perimenopause [Internet]. London: NHS; 2026 [cited 2026 Sep 8]. Available from: https://www.nhs.uk/conditions/menopause-and-perimenopause/treatment/
2. NHS. Types of hormone replacement therapy (HRT) [Internet]. London: NHS; 2026 [cited 2026 Sep 8]. Available from: https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/types-of-hormone-replacement-therapy-hrt/
3. National Institute for Health and Care Excellence. Menopause: diagnosis and management (NG23) [Internet]. London: NICE; 2015 [updated 2026 Apr 15; cited 2026 Sep 8]. Available from: https://www.nice.org.uk/guidance/ng23
4. Eli Lilly and Company Limited. Mounjaro KwikPen 5 mg solution for injection in pre-filled pen: Summary of Product Characteristics [Internet]. Leatherhead: electronic Medicines Compendium; 2026 [cited 2026 Sep 8]. Available from: https://www.medicines.org.uk/emc/product/15482/smpc
5. Novo Nordisk Limited. Wegovy 2.4 mg, FlexTouch solution for injection in pre-filled pen: Summary of Product Characteristics [Internet]. London: electronic Medicines Compendium; 2026 [cited 2026 Sep 8]. Available from: https://www.medicines.org.uk/emc/product/13803/smpc
6. Novo Nordisk Limited. Wegovy 1.5 mg tablets: Summary of Product Characteristics [Internet]. London: electronic Medicines Compendium; 2026 [cited 2026 Sep 8]. Available from: https://www.medicines.org.uk/emc/product/102344/smpc