Lifestyle
Understanding Obesity: The Gut-Brain Axis

What we’ll cover:

  • What the gut-brain axis is
  • How the gut microbiome is linked to obesity
  • Tips for improving your gut health

You may have heard that many things can affect body weight, like genetics, lifestyle, and the world around us. But did you know that tiny microbes in your gut can also play a big role? Research shows that these gut microbes can influence mood, metabolism (how your body uses energy), and even how easy or hard it is to manage weight.

The Gut-Brain Axis

Your gut and brain are connected by a two-way communication system called the gut-brain axis. The trillions of microbes in your gut, known as the gut microbiome, are key players in this system. These microbes produce substances that affect not just your digestion but also your immune system and even your mood.

Your gut and brain are connected and constantly send messages to each other. This connection is called the gut-brain axis. Inside your gut, there are trillions of tiny microbes- this is known as the gut microbiome. These microbes do more than help with digestion. They also support your immune system and can even affect your mood.

The vagus nerve is like a communication highway between your brain, heart, and gut. It helps them work together by sending messages back and forth. Your body also uses hormones to manage hunger. Ghrelin tells you when you're hungry, while leptin lets you know when you're full. But if these signals get mixed up, your body can become confused. This can make it harder to know when to stop eating, which may lead to weight gain.

The Gut Microbiome's Role in Obesity

Research shows that people living with obesity often have less variety in their gut bacteria. This imbalance can affect the body in several ways, including:

  • Changing how food is processed, which can lead to more fat being stored
  • Increasing inflammation, which is linked to weight gain
  • Affecting hormones that control hunger and blood sugar levels

Some gut bacteria even produce substances that can change appetite and how the body uses insulin, a hormone that helps manage blood sugar.

Simple Ways to Support Gut Health

Looking after your gut bacteria can help with weight management and overall well-being. Here are some simple ways to support a healthy gut:

  • Eat a mix of foods- Include colourful fruits, vegetables, whole grains, and beans or lentils. These are full of fibre, which feeds good gut bacteria.
  • Try fermented foods - Yoghurt, kefir, sauerkraut, and kimchi contain probiotics- helpful bacteria that support gut health.
  • Cut down on ultra-processed foods - Too many processed foods can upset the balance of bacteria in your gut. When possible, choose whole, less processed options.
  • Drink plenty of water - Staying hydrated helps digestion and creates a healthy environment for gut microbes.
  • Manage stress- Stress can affect your gut. Taking time to relax, practise mindfulness, or eat slowly can help.
  • Move your body - Regular physical activity can improve the variety of your gut bacteria and support your overall health.

Summary:

The link between your gut and brain plays a big role in weight, mood, and overall well-being. Understanding how gut bacteria affect the body can help you make simple, positive changes. Eating a variety of foods, staying active, managing stress, and practising mindful eating can all support a healthy gut. These small, lasting habits can help with weight management and improve your overall health and happiness.

February 19, 2025
Written by
RGN Tiago Grohmann
Reviewed by
Dr Claudia Ashton
References:

Agustí, A., García-Pardo, M. P., López-Almela, I., Campillo, I., Maes, M., Romaní-Pérez, M., & Sanz, Y. (2018). Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function. Frontiers in neuroscience, 12, 155. https://doi.org/10.3389/fnins.2018.00155

Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 13(10), 701-712. https://doi.org/10.1038/nrn3346

Longo, S., Rizza, S., & Federici, M. (2023). Microbiota-gut-brain axis: Relationships among the vagus nerve, gut microbiota, obesity, and diabetes. Acta Diabetologica, 60, 1007–1017. https://doi.org/10.1007/s00592-023-02088-x

van Son, J., Koekkoek, L. L., La Fleur, S. E., Serlie, M. J., & Nieuwdorp, M. (2021). The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications. International Journal of Molecular Sciences, 22(6), 2993. https://doi.org/10.3390/ijms22062993

Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2014). Gut microbes and the brain: Paradigm shift in neuroscience. The Journal of Neuroscience, 34(46), 15490-15496. https://doi.org/10.1523/JNEUROSCI.3299-14.2014

Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., ... & Gordon, J. I. (2013). Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science, 341(6150), 1241214. https://doi.org/10.1126/science.1241214

Sweeney, T. E., & Morton, J. M. (2013). The human gut microbiome: A review of the effect of obesity and surgically induced weight loss. JAMA Surgery, 148(6), 563-569. https://doi.org/10.1001/jamasurg.2013.5

Matthew R. Hilimire, Jordan E. DeVylder, Catherine A. Forestell. (2015) Fermented foods, neuroticism, and social anxiety: An interaction model. Psychiatry Research. 228(2) p 203-208

Bayes, Jessica & Schloss, Janet & Sibbritt, David. (2019). Effects of Polyphenols in a Mediterranean Diet on Symptoms of Depression: A Systematic Literature Review. Advances in Nutrition. 11. 10.1093/advances/nmz117.

Recchia F, Leung CK, Chin EC (2022) Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine. 56 p1375-1380.

Copied to clipboard!

This link is only accessible via the Roczen app